N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

Base Information

Chemical Name:N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine
CAS No.:945396-63-4
Molecular Formula:C₂₇H₃₂N₈O₂
Molecular Weight:500.603
Hs Code.:

Synonyms:N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

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Chemical Property of N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

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Technology Process of N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

There total 9 articles about N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 945397-12-6
N-(3,5-dimorpholin-4-ylphenyl)-N'-[1-[(4-methoxyphenyl)methyl]-3-methyl-indazol-4-yl]-N'-methyl-pyrimidine-2,4-diamine

: 945396-63-4
N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 130 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 945396-63-4
N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2.5 h / 17 - 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 2.5 h / 70 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

4.1: hydrogen / platinum(IV) oxide / ethanol / 1 h / 17 - 25 °C / 760.05 Torr

5.1: hydrogenchloride / butan-1-ol; 1,4-dioxane / 2 h / 80 °C

6.1: caesium carbonate / acetonitrile / 18 h / 17 - 25 °C

7.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 1.5 h / 17 - 25 °C / Cooling with ice

8.1: hydrogenchloride / 1,4-dioxane; pentanol, 2- / 0.5 h / 150 °C / microwave synthesisor

9.1: trifluoroacetic acid; methoxybenzene / 0.67 h / 130 °C / Microwave irradiation

With hydrogenchloride; potassium tert-butylate; hydrogen; iodine; caesium carbonate; methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium hydroxide; platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; pentanol, 2-; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;

Reference yield:

: 945397-06-8
3-iodo-1-[(4-methoxyphenyl)methyl]-4-nitro-indazole

: 945396-63-4
N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-N'-(3-methyl-1H-indazol-4-yl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 7 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

2: hydrogen / platinum(IV) oxide / ethanol / 1 h / 17 - 25 °C / 760.05 Torr

3: hydrogenchloride / butan-1-ol; 1,4-dioxane / 2 h / 80 °C

4: caesium carbonate / acetonitrile / 18 h / 17 - 25 °C

5: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 1.5 h / 17 - 25 °C / Cooling with ice

6: hydrogenchloride / 1,4-dioxane; pentanol, 2- / 0.5 h / 150 °C / microwave synthesisor

7: trifluoroacetic acid; methoxybenzene / 0.67 h / 130 °C / Microwave irradiation

With hydrogenchloride; hydrogen; caesium carbonate; methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; pentanol, 2-; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;