4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Base Information

Chemical Name:4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide
CAS No.:1579939-44-8
Molecular Formula:C₁₆H₁₄FN₅O₃S₂
Molecular Weight:407.449
Hs Code.:

Synonyms:4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

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Chemical Property of 4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Chemical Property:

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Technology Process of 4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

There total 6 articles about 4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

: 1579939-43-7
C₂₀H₂₂FN₅O₃S₂

: 1579939-44-8
4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃; for 24h;
DOI:10.1039/c3ob41936c

Reference yield:

: 99987-05-0
4-tert-butylsulfamoyl-benzoic acid

: 1579939-44-8
4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrazine hydrate / ethanol / 6 h / Reflux

3.1: ethanol / 5 h / Reflux

4.1: sodium hydroxide / methanol / 2 h / Reflux

4.2: pH 2

5.1: potassium carbonate / acetone / 0.5 h / 50 °C

5.2: 3 h / Reflux

6.1: trifluoroacetic acid / 24 h / 0 - 20 °C

With potassium carbonate; hydrazine hydrate; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1039/c3ob41936c

Reference yield:

: 100371-33-3
4-tert-butylsulfamoyl-benzoic acid methyl ester

: 1579939-44-8
4-(4-(4-fluorophenyl)-5-(2-(hydroxyimino)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethanol / 6 h / Reflux

2.1: ethanol / 5 h / Reflux

3.1: sodium hydroxide / methanol / 2 h / Reflux

3.2: pH 2

4.1: potassium carbonate / acetone / 0.5 h / 50 °C

4.2: 3 h / Reflux

5.1: trifluoroacetic acid / 24 h / 0 - 20 °C

With potassium carbonate; hydrazine hydrate; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; acetone;
DOI:10.1039/c3ob41936c