Technology Process of 1-(4-benzyl-2,5-dimethoxyphenyl)-2-aminopropane
There total 4 articles about 1-(4-benzyl-2,5-dimethoxyphenyl)-2-aminopropane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / 2 h / Ambient temperature
2: 48 percent / titanium tetrachloride / CH2Cl2 / 1.) -30 deg C, 30 min, 2.) RT, 3 d
3: 61 percent / H2, 60percent aq. HClO4 / 10percent Pd/C / acetic acid / 6 h
4: 15percent aq. NaOH / methanol / 2.5 h / Heating
With
sodium hydroxide; perchloric acid; hydrogen; titanium tetrachloride;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00165a023
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 48 percent / titanium tetrachloride / CH2Cl2 / 1.) -30 deg C, 30 min, 2.) RT, 3 d
2: 61 percent / H2, 60percent aq. HClO4 / 10percent Pd/C / acetic acid / 6 h
3: 15percent aq. NaOH / methanol / 2.5 h / Heating
With
sodium hydroxide; perchloric acid; hydrogen; titanium tetrachloride;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00165a023
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 61 percent / H2, 60percent aq. HClO4 / 10percent Pd/C / acetic acid / 6 h
2: 15percent aq. NaOH / methanol / 2.5 h / Heating
With
sodium hydroxide; perchloric acid; hydrogen;
palladium on activated charcoal;
In
methanol; acetic acid;
DOI:10.1021/jm00165a023