1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Base Information

Chemical Name:1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone
CAS No.:139774-02-0
Molecular Formula:C₂₅H₂₇FN₄O
Molecular Weight:418.514
Hs Code.:

Synonyms:1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

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Chemical Property of 1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

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Technology Process of 1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

There total 5 articles about 1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2387-20-4
1-(2-chloroethyl)imidazolidin-2-one

: 139774-01-9
1-(4-fluorophenyl)-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

: 139774-02-0
1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: With potassium carbonate; potassium iodide; In various solvent(s); for 16h; Heating;
DOI:10.1021/jm00104a006

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 139774-02-0
1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / KOH, CuO / dimethylformamide / 6 h / Heating

2: 87 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: H₂ / 5percent Pd/C-H₂O / ethanol / 20 h / 1520 - 2280 Torr

4: 98 percent / CF₃CO₂H, CH₃CO₂H / 0.83 h / Heating

5: 49 percent / K₂CO₃, KI / various solvent(s) / 16 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; copper(II) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00104a006

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 139774-02-0
1-<2-<4-<1-(4-fluorophenyl)-2-methyl-1H-indol-3-yl>-1,2,3,6-tetrahydropyridin-1-yl>ethyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / KOH, CuO / dimethylformamide / 6 h / Heating

2: 87 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: H₂ / 5percent Pd/C-H₂O / ethanol / 20 h / 1520 - 2280 Torr

4: 98 percent / CF₃CO₂H, CH₃CO₂H / 0.83 h / Heating

5: 49 percent / K₂CO₃, KI / various solvent(s) / 16 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; copper(II) oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00104a006