Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate

Base Information

• Chemical Name: Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate
• CAS No.: 131843-97-5
• Molecular Formula: C₁₂H₁₁BrClN₃O₃
• Molecular Weight: 360.595
• Mol file: 131843-97-5.mol

Synonyms:Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate

Chemical Property of Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate

There total 3 articles about Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Methyl 1-(4-Chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate (131843-68-0) → Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate (131843-97-5)

Guidance literature:

With bromine; In acetic acid; at 45 ℃; for 1h;

DOI:10.1002/hlca.19900730615

Reference yield:

Dimethyl 2-(2-Chloro-N-methylacetamido)malonate (131843-54-4) → Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate (131843-97-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 5 M aq. NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

2: 88 percent / NaOMe / methanol / 1 h / 0 °C

3: 85 percent / Br₂ / acetic acid / 1 h / 45 °C

With hydrogenchloride; bromine; sodium methylate; potassium carbonate; acetic acid; sodium nitrite; In methanol; acetic acid;

DOI:10.1002/hlca.19900730615

Reference yield:

Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-chlorophenylazo)malonate (131843-61-3) → Methyl 6-Bromo-1-(4-chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate (131843-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / NaOMe / methanol / 1 h / 0 °C

2: 85 percent / Br₂ / acetic acid / 1 h / 45 °C

With bromine; sodium methylate; In methanol; acetic acid;

DOI:10.1002/hlca.19900730615

upstream raw materials:

Methyl 1-(4-Chlorophenyl)-1,4,5,6-tetrahydro-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate

Dimethyl 2-(2-Chloro-N-methylacetamido)malonate

Dimethyl 2-(2-Chloro-N-methylacetamido)-2-(4-chlorophenylazo)malonate

Downstream raw materials:

Methyl 1-(4-Chlorophenyl)-1,4,5,6-tetrahydro-6-hydroxy-4-methyl-5-oxo-1,2,4-triazine-3-carboxylate