(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

Base Information

Chemical Name:(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane
CAS No.:916045-28-8
Molecular Formula:C₄₆H₇₈O₅Si
Molecular Weight:739.208
Hs Code.:

(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

Synonyms:(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

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Chemical Property of (R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

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Technology Process of (R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

There total 3 articles about (R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 916045-27-7
(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-propanol

: 916045-41-5
1-bromo-3,8,8,14,18-pentamethyl-11-methylene-nonadeca-2,6,13,17-tetraene

: 916045-28-8
(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

Guidance literature:: (R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-propanol; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

1-bromo-3,8,8,14,18-pentamethyl-11-methylene-nonadeca-2,6,13,17-tetraene; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ja065905c

Reference yield:

: 152563-54-7
2,3-epoxy-1-[(triisopropylsilyl)oxy]propane

: 916045-28-8
(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / CoOTf/chiral bis(iminophenoxy)-functionalized oligomer / acetonitrile / 24 h / 4 °C

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

2.2: 66 percent / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

With sodium hydride; chiral bis(iminophenoxy)-functionalized oligomer; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja065905c

Reference yield:

: 19953-93-6
(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tetraen-1-ol

: 916045-28-8
(R)-3-(3,4-dimethoxybenzyloxy)-1-triisopropylsilyloxy-2-[(2Z,6E,13E)-3,8,8,14,18-pentamethyl-11-methylenenonadeca-2,6,13,17-tertaen-1-yloxy]propane

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus tribromide / diethyl ether / 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

2.2: 66 percent / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

With phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja065905c