tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

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Chemical Name:tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane
CAS No.:887137-74-8
Molecular Formula:C₃₈H₆₀O₅Si
Molecular Weight:624.977
Hs Code.:

tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

Synonyms:tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

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Technology Process of tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

There total 20 articles about tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 887137-73-7
(2R,5S,6R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-3,5-dimethoxy-4-methyl-6-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenyl]-5-methyl-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-4-one

: 887137-74-8
tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

Guidance literature:: In tetrahydrofuran; hexane; at 60 ℃; for 12h;
DOI:10.1021/ja060369+

Reference yield:

: 853995-88-7
(2S,3R,6S)-3-Hydroxy-2,6-dimethyl-oct-7-enoic acid

: 887137-74-8
tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / isopropyloxytrimethylsilane; TMSOTf / CH₂Cl₂ / 12 h / -20 °C

2: 87 percent / tetrahydrofuran; hexane / 12 h / 60 °C

With isopropoxytrimethylsilane; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; dichloromethane; 1: Kurihara condensation / 2: Petasis-Tebbe reaction;
DOI:10.1021/ja060369+

Reference yield:

: 853996-02-8
(R)-5-Iodo-2,4-dimethyl-pent-1-ene

: 887137-74-8
tert-Butyl-[2,4-dimethoxy-3-methyl-6-[(2R,5S,6R)-5-methyl-4-methylene-6-((S)-3-methyl-pent-4-enyl)-[1,3]dioxan-2-yl]-5-((3S,5S)-3,5,7-trimethyl-oct-7-en-1-ynyl)-phenoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA; LiCl / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

1.2: 98 percent / tetrahydrofuran; hexane / 14 h / 20 °C

2.1: 97 percent / LDA; BH₃*NH₃ / tetrahydrofuran; hexane / 3 h / 20 °C

3.1: 89 percent / Et₃N; SO₃*Py; DMSO / CH₂Cl₂ / 1 h / 0 °C

4.1: t-BuOK / tetrahydrofuran / 0.25 h / -78 °C

4.2: 77 percent / tetrahydrofuran / 1 h / -78 °C

5.1: 85 percent / PdCl₂(PPh₃)2; CuI; diisopropylamine / 6.5 h / 60 °C

6.1: 26 percent / isopropyloxytrimethylsilane; TMSOTf / CH₂Cl₂ / 12 h / -20 °C

7.1: 87 percent / tetrahydrofuran; hexane / 12 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; borane-ammonia complex; pyridine-SO₃ complex; isopropoxytrimethylsilane; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; dimethyl sulfoxide; triethylamine; diisopropylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; 1.2: Myers alkylation / 3.1: Parikh-Doering oxidation / 5.1: Sonogashira reaction / 6.1: Kurihara condensation / 7.1: Petasis-Tebbe reaction;
DOI:10.1021/ja060369+