Technology Process of bis(1-methyl-1H-1,2,3-triazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methanol
There total 5 articles about bis(1-methyl-1H-1,2,3-triazol-5-yl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-iodo-3-phenyl-2,4-bis(trifluoromethyl)quinoline;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
for 0.0666667h;
Inert atmosphere;
bis(1-methyl-1H-1,2,3-triazol-5-yl)methanone;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Inert atmosphere;
With
water; ammonium chloride;
In
tetrahydrofuran;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.1 h / -68 °C / Inert atmosphere; Cooling with acetone-dry ice
1.2: Inert atmosphere
2.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C
2.2: 0.5 h / 20 °C
3.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C
4.1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / tert-butyl alcohol / 0.5 h / 150 °C / Microwave irradiation
5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.07 h / Ca.-70 -20 °C / Inert atmosphere
5.2: 3 h / 20 °C / Inert atmosphere
5.3: Inert atmosphere
With
copper(l) iodide; n-butyllithium; sodium azide; tributyl-amine; isopropylmagnesium chloride; diisopropylamine; sodium iodide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C
1.2: 0.5 h / 20 °C
2.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C
3.1: copper(l) iodide; N,N`-dimethylethylenediamine; sodium iodide / tert-butyl alcohol / 0.5 h / 150 °C / Microwave irradiation
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.07 h / Ca.-70 -20 °C / Inert atmosphere
4.2: 3 h / 20 °C / Inert atmosphere
4.3: Inert atmosphere
With
copper(l) iodide; sodium azide; tributyl-amine; isopropylmagnesium chloride; sodium iodide; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
