tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

Base Information

Chemical Name:tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate
CAS No.:161282-54-8
Molecular Formula:C₁₉H₂₃NO₄S
Molecular Weight:361.462
Hs Code.:

Synonyms:tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

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Chemical Property of tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

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Technology Process of tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

There total 5 articles about tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 161282-36-6
tert-butyl (Z)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)prop-2-enoate

: 161282-54-8
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

Guidance literature:: With hydrogen; BF4; In methanol; at 40 ℃; under 45003.6 Torr;
DOI:10.1002/hlca.19940770518

Reference yield:

: 498-62-4
3-thiophene carboxaldehyde

: 161282-54-8
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 81.2 percent / N,N,N',N'-tetramethylguanidine / CH₂Cl₂ / 0.5 h / -30 °C

2: 99.5 percent / hydrogen / BF₄ / methanol / 40 °C / 45003.6 Torr

With hydrogen; N,N,N',N'-tetramethylguanidine; BF4; In methanol; dichloromethane;
DOI:10.1002/hlca.19940770518

Reference yield:

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 161282-54-8
tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-3-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 2 N aq. NaOh / dioxane

2: 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C -> room temperature

3: 81.2 percent / N,N,N',N'-tetramethylguanidine / CH₂Cl₂ / 0.5 h / -30 °C

4: 99.5 percent / hydrogen / BF₄ / methanol / 40 °C / 45003.6 Torr

With dmap; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; N,N,N',N'-tetramethylguanidine; BF4; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/hlca.19940770518