benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Base Information

Chemical Name:benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate
CAS No.:1448350-20-6
Molecular Formula:C₃₁H₂₄N₆O₅
Molecular Weight:560.569
Hs Code.:

Synonyms:benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Suppliers and Price of benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

There total 7 articles about benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1004647-09-9
benzyl 4-amino-3-nitrobenzoate

: C₁₇H₁₃ClN₄O

: 1448350-20-6
benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Guidance literature:: With pyridine; sodium hydride; In mineral oil; at -10 - 20 ℃; for 2.08333h; Inert atmosphere;
DOI:10.1021/jm400634n

Reference yield:

: 1588-83-6
4-amino-3-nitrobenzoic acid

: 1448350-20-6
benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 18 h / 20 °C / Alkaline conditions

2: pyridine; sodium hydride / mineral oil / 2.08 h / -10 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm400634n

Reference yield:

: 849235-67-2
methyl 4-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzoate

: 1448350-20-6
benzyl 3-nitro-4-{[4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzene]amido}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide; water / 24 h / 20 °C

2: thionyl chloride / toluene / 3 h / Reflux

3: pyridine; sodium hydride / mineral oil / 2.08 h / -10 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; water; sodium hydride; lithium hydroxide; In toluene; mineral oil;
DOI:10.1021/jm400634n