(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

Base Information

Chemical Name:(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester
CAS No.:210753-54-1
Molecular Formula:C₄₇H₅₇N₃O₃S₂
Molecular Weight:776.12
Hs Code.:

(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

Synonyms:(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

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Chemical Property of (S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

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Technology Process of (S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

There total 6 articles about (S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 150350-28-0
S-trityl 3-mercaptopropionaldehyde

: N-(2(S)-amino-3(S)-methylpentyl)-N-(1-naphthylmethyl)-glycyl-methionine methyl ester hydrochloride

: 210753-54-1
(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

Guidance literature:: With 3 A molecular sieve; potassium acetate; sodium cyanoborohydride; In methanol; for 18h; Ambient temperature;
DOI:10.1021/jm9800907

Reference yield:

: 118171-79-2,141321-51-9,141321-54-2,87694-55-1
N-(t-butoxycarbonyl)-isoleucine aldehyde

: 210753-54-1
(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide / 18 h

2: 3.8 g / Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / 16 h / Ambient temperature

3: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

4: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

5: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

6: 79 percent / KOAc, NaCNBH₃, 3A molecular sieves / methanol / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 168539-97-7
N-(2(S)-(t-butoxycarbonylamino)-3(S)-methylpentyl)glycine methyl ester

: 210753-54-1
(S)-4-Methylsulfanyl-2-(2-{[(2S,3S)-3-methyl-2-(3-tritylsulfanyl-propylamino)-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 3.8 g / Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / 16 h / Ambient temperature

2: 2.29 g / 1 N aq. NaOH / methanol / 4 h / Ambient temperature

3: 2.82 g / HOBT, EDC, Et₃N / dimethylformamide / 24 h / Ambient temperature

4: 2.68 g / HCl (gas) / ethyl acetate / -25 °C

5: 79 percent / KOAc, NaCNBH₃, 3A molecular sieves / methanol / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; 3 A molecular sieve; potassium acetate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907