(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:380223-07-4
Molecular Formula:C₁₆H₁₈N₄O₄
Molecular Weight:330.343
Hs Code.:

Synonyms:(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of (S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of (S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 3 articles about (S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 34897-85-3
o-azidobenzoyl chloride

: 35418-16-7,85136-12-5
L-t-butyl pyroglutamate

: 380223-07-4
(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 380223-07-4
(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaNO₂; aq. HCl; NaN₃ / NaOAc

2: SOCl₂

3: LDA

With hydrogenchloride; thionyl chloride; sodium azide; lithium diisopropyl amide; sodium nitrite; sodium acetate;
DOI:10.1016/j.bmcl.2005.06.046

Reference yield:

: 31162-13-7
2-azidobenzoic acid

: 380223-07-4
(S)-1-(2-Azido-benzoyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂

2: LDA

With thionyl chloride; lithium diisopropyl amide;
DOI:10.1016/j.bmcl.2005.06.046