(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

Base Information

Chemical Name:(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate
CAS No.:1380230-90-9
Molecular Formula:C₁₄H₁₅N₅O₄
Molecular Weight:317.304
Hs Code.:

Synonyms:(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

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Chemical Property of (S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

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Technology Process of (S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

There total 7 articles about (S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74124-79-1
di(succinimido) carbonate

: 1380230-82-9
C₉H₁₂N₄

: 1380230-90-9
(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

Guidance literature:: In dichloromethane; for 3h;
DOI:10.1021/ol3012106

Reference yield:

: 1380230-80-7
C₁₇H₁₄N₄O₂

: 1380230-90-9
(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 4 h / Reflux

2: dichloromethane / 3 h

With hydrazine hydrate; In methanol; dichloromethane;
DOI:10.1021/ol3012106

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1380230-90-9
(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -20 °C / Inert atmosphere

1.2: 0.33 h / -20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 0.5 h

3.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate / methanol / 20 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

5.1: hydrazine hydrate / methanol / 4 h / Reflux

6.1: dichloromethane / 3 h

With 4-methyl-morpholine; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; di-isopropyl azodicarboxylate; potassium carbonate; hydrazine hydrate; triphenylphosphine; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid; 4.1: Mitsunobu reaction;
DOI:10.1021/ol3012106