dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

Base Information

Chemical Name:dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate
CAS No.:1298016-22-4
Molecular Formula:C₂₁H₂₄O₅
Molecular Weight:356.419
Hs Code.:

Synonyms:dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

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Chemical Property of dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

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Technology Process of dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

There total 9 articles about dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: C₂₁H₂₄O₅

: 1298016-22-4
dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

Guidance literature:: With bis(norbornadiene)rhodium(l)tetrafluoroborate; In dichloromethane; at 20 ℃; stereoselective reaction;
DOI:10.1021/acscatal.6b03399

Reference yield:

: C₇H₁₁BrO

: 1298016-22-4
dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

: (1SR,5RS,6RS)-dimethyl1-benzoyl-6-(2-methylprop-1-enyl)bicyclo[3.1.0]hexane-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

1.2: 4 h / -78 °C

2.1: silver hexafluoroantimonate / 1,2-dichloro-ethane / 2 h / 75 °C

With silver hexafluoroantimonate; sodium hydride; In tetrahydrofuran; 1,2-dichloro-ethane; mineral oil;
DOI:10.1021/ja2014604

Reference yield:

: 1298016-32-6
(E)-3-(3,3-dimethyloxiran-2-yl)prop-2-en-1-ol

: 1298016-22-4
dimethyl 3,3-dimethyl-1-phenyl-5a,6-dihydro-3H-cyclopenta[c]oxepine-7,7(8H)-dicarboxylate

: (1SR,5RS,6RS)-dimethyl1-benzoyl-6-(2-methylprop-1-enyl)bicyclo[3.1.0]hexane-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h

1.2: 2.5 h / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 4 h / -78 °C

3.1: silver hexafluoroantimonate / 1,2-dichloro-ethane / 2 h / 75 °C

With silver hexafluoroantimonate; n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; 1,2-dichloro-ethane; mineral oil;
DOI:10.1021/ja2014604