N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Base Information

• Chemical Name: N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide
• CAS No.: 160495-76-1
• Molecular Formula: C₄₃H₅₀N₁₀O₈
• Molecular Weight: 834.932

Synonyms:N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

Chemical Property of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

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Technology Process of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

There total 1 articles about N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(R)-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (96922-00-8) + erythro-N?-Triphenylmethyl-β-hydroxy-L-histidinmethylester (142582-33-0) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(R)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (160495-76-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 72h;

Reference yield: 97.0%

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(R)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (160495-76-1) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(R)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (160495-77-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at -10 ℃; for 1h;

Reference yield:

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(R)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide (160495-76-1) → Nα-((tert-butyloxy)carbonyl)-Nim-(triphenylmethyl)epideglycobleomycin A2

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 1 N aq. LiOH / tetrahydrofuran; methanol / 1 h / -10 °C

2: 79 percent / DCC, HOBt, NaHCO₃ / dimethylformamide / 72 h / 23 °C

With lithium hydroxide; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

erythro-N^?-Triphenylmethyl-β-hydroxy-L-histidinmethylester

Downstream raw materials:

N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(R)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-(S)-β-aminoalanine amide

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