(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one
CAS No.:127061-41-0
Molecular Formula:C₂₆H₂₀F₃NO₆
Molecular Weight:499.443
Hs Code.:

Synonyms:(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

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Chemical Property of (cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

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Technology Process of (cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

There total 10 articles about (cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 127061-43-2
(3R-cis)-3-(hydroxy)-1,3,4,5-tetrahydro-4-[4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

: 127061-41-0
(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: With dmap; triethylamine; In dichloromethane;

Reference yield:

: 6656-49-1
2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 127061-41-0
(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / NaH / dimethylformamide / 20 h / 28 - 30 °C

2: 95 percent / H₂ / 5percent Pd/C / methanol

3: 97 percent / NaOMe / methanol / Heating

4: O₂, potassium hexamethyldisilazide, P(OEt)3 / tetrahydrofuran

5: LiI / pyridine; H₂O / 100 °C

6: 100 percent / Et₃N, DMAP / CH₂Cl₂

With dmap; hydrogen; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; triethylamine; lithium iodide; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 7443-25-6
dimethyl 2-(4-methoxybenzylidene)malonate

: 127061-41-0
(cis)-3-[(2-Carboxybenzoyl)oxy]-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / NaH / dimethylformamide / 20 h / 28 - 30 °C

2: 95 percent / H₂ / 5percent Pd/C / methanol

3: 97 percent / NaOMe / methanol / Heating

4: O₂, potassium hexamethyldisilazide, P(OEt)3 / tetrahydrofuran

5: LiI / pyridine; H₂O / 100 °C

6: 100 percent / Et₃N, DMAP / CH₂Cl₂

With dmap; hydrogen; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; triethylamine; lithium iodide; triethyl phosphite; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;