1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI)
• CAS No.: 786693-66-1
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.255
• Mol file: 786693-66-1.mol

Synonyms:1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI)

Chemical Property of 1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI)

There total 3 articles about 1H-Pyrrolizine-1-methanamine,hexahydro-7a-methyl-,(1R,7aR)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-((1S,7aS)-7a-Methyl-hexahydro-pyrrolizin-1-ylmethyl)-isoindole-1,3-dione → C-((1R,7aR)-7a-Methyl-hexahydro-pyrrolizin-1-yl)-methylamine (786693-66-1)

Guidance literature:

With hydrazine hydrate;

DOI:10.1016/j.bmcl.2004.04.021

Reference yield:

(7a-methyl-hexahydro-pyrrolizin-1-yl)-methanol (727705-47-7) → C-((1R,7aR)-7a-Methyl-hexahydro-pyrrolizin-1-yl)-methylamine (786693-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P; DEAD / tetrahydrofuran

2: 100 percent / H₂NNH₂*H₂O

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2004.04.021

Reference yield:

7a-methyl-5-oxo-hexahydro-pyrrolizine-1-carboxylic acid methyl ester → C-((1R,7aR)-7a-Methyl-hexahydro-pyrrolizin-1-yl)-methylamine (786693-66-1)

Guidance literature:

Multi-step reaction with 3 steps

1: LAH / tetrahydrofuran

2: Ph₃P; DEAD / tetrahydrofuran

3: 100 percent / H₂NNH₂*H₂O

With lithium aluminium tetrahydride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;

DOI:10.1016/j.bmcl.2004.04.021

upstream raw materials:

(7a-methyl-hexahydro-pyrrolizin-1-yl)-methanol