3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

Base Information

Chemical Name:3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol
CAS No.:1619982-81-8
Molecular Formula:C₂₂H₃₀O₂
Molecular Weight:326.479
Hs Code.:

Synonyms:3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

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Chemical Property of 3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

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Technology Process of 3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

There total 3 articles about 3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1619982-79-4
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3-methoxy-5-methylphenyl)methanone

: 1619982-81-8
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

: 1619982-80-7
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

Guidance literature:: With sodium sulfide; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 0.5h; Overall yield = 78 %; Overall yield = 71 mg; Microwave irradiation; Sealed tube;

Reference yield:

: 1000009-66-4
(1S,2R,4aS,8aS)-1-[hydroxy(3-methoxy-5-methylphenyl)methyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619982-81-8
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

: 1619982-80-7
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

2: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3: sodium sulfide / 1-methyl-pyrrolidin-2-one / 0.5 h / 180 °C / Microwave irradiation; Sealed tube

With sodium sulfide; tin(IV) chloride; pyridinium chlorochromate; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 1619982-78-3
(1R,2R,4aS,8aS)-1-[(3-methoxy-5-methylphenyl)carbonyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619982-81-8
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

: 1619982-80-7
3-{[(4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]carbonyl}-5-methylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2: sodium sulfide / 1-methyl-pyrrolidin-2-one / 0.5 h / 180 °C / Microwave irradiation; Sealed tube

With sodium sulfide; tin(IV) chloride; In 1-methyl-pyrrolidin-2-one; dichloromethane;