diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

Base Information

Chemical Name:diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate
CAS No.:1373931-82-8
Molecular Formula:C₃₅H₄₄N₂O₁₇
Molecular Weight:764.738
Hs Code.:

diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

Synonyms:diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

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Chemical Property of diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

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Technology Process of diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

There total 5 articles about diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1373931-80-6
2-(4,5-bis(ethoxycarbonylmethoxy)-2-nitrophenyl)-2-bromoacetic acid ethoxycarbonylmethyl ester

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1373931-82-8
diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

Guidance literature:: (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester; With caesium carbonate; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-(4,5-bis(ethoxycarbonylmethoxy)-2-nitrophenyl)-2-bromoacetic acid ethoxycarbonylmethyl ester; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/c2pp05320a

Reference yield:

: 1373931-79-3
2-(4,5-bis(ethoxycarbonylmethoxy)-2-nitrophenyl)acetic acid ethoxycarbonylmethyl ester

: 1373931-82-8
diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h

1.2: 3 h / Darkness

2.1: hydrogen bromide / dichloromethane; acetic acid / 0.5 h

3.1: caesium carbonate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

With hydrogen bromide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/c2pp05320a

Reference yield:

: 1373931-89-5
2-(3,4-bis(ethoxycarbonylmethoxy)phenyl)acetic acid ethoxycarbonylmethyl ester

: 1373931-82-8
diethyl 2,2'-((4-(1-(4-((S)-2-((t-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenoxy)-2-(2-ethoxy-2-oxoethoxy)-2-oxoethyl)-5-nitro-1,2-phenylene)bis(oxy))diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid / dichloromethane / 0.5 h / 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h

2.2: 3 h / Darkness

3.1: hydrogen bromide / dichloromethane; acetic acid / 0.5 h

4.1: caesium carbonate / tetrahydrofuran / 0.5 h / 0 °C

4.2: 20 °C

With hydrogen bromide; nitric acid; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;
DOI:10.1039/c2pp05320a