(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

Base Information

Chemical Name:(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one
CAS No.:84939-48-0
Molecular Formula:C₂₁H₂₅NO₇S
Molecular Weight:435.498
Hs Code.:

Synonyms:(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

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Chemical Property of (3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

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Technology Process of (3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

There total 7 articles about (3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 84939-43-5
(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-hydroxy-ethyl)-azetidin-2-one

: 107-30-2
chloromethyl methyl ether

: 84939-48-0
(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

Guidance literature:: With N,N-diethylaniline; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1016/S0040-4039(00)81597-X

Reference yield:

: 7205-91-6
phenylthiomethyl chloride

: 84939-48-0
(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50percent aq. NaOH / benzyltriethylammonium iodide / CH₂Cl₂ / 1 h / Ambient temperature

2: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

3: 71 percent / n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -50 °C

4: 94 percent / N,N-diethylaniline / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; triethylbenzylammonium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4039(00)81597-X

Reference yield:

: 84939-35-5
(2R,3R)-3-Methyl-oxirane-2-carboxylic acid (3,4-dimethoxy-phenyl)-amide

: 84939-48-0
(3S,4R)-4-Benzenesulfonyl-1-(3,4-dimethoxy-phenyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50percent aq. NaOH / benzyltriethylammonium iodide / CH₂Cl₂ / 1 h / Ambient temperature

2: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

3: 71 percent / n-butyllithium / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -50 °C

4: 94 percent / N,N-diethylaniline / CH₂Cl₂ / 16 h / Ambient temperature

With sodium hydroxide; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; triethylbenzylammonium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4039(00)81597-X