tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate
CAS No.:1261071-81-1
Molecular Formula:C₃₄H₅₃N₃O₄Si₂
Molecular Weight:623.984
Hs Code.:

tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

Synonyms:tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179942-45-1
(6-((tert-butyldimethylsilyl)oxy)naphthalen-2-yl)boronic acid

: 1179151-57-5
(S)-tert-butyl 2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261071-81-1
tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 120 ℃; for 0.333333h; microwave irradiation;

Reference yield:

: 1261071-81-1
tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

: 1261071-84-4
tert-butyl (2S)-2-(5-[6-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)naphthalen-2-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

2: triethylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation

With tetrabutyl ammonium fluoride; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1261071-81-1
tert-butyl (2S)-2-[5-(6-{[tert-butyl(dimethyl)silyl]oxy}naphthalen-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

: 1261070-47-6
methyl {(2S)-1-[(2S)-2-{5-[4-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]butanoyl}pyrrolidin-2-yl]-1H-imidazol-5-yl}naphthalen-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 5 h / 75 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h

5.2: 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;