1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

Base Information

Chemical Name:1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride
CAS No.:1047673-68-6
Molecular Formula:C₁₈H₁₈F₃N₃O₂S*ClH
Molecular Weight:433.882
Hs Code.:

Synonyms:1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

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Chemical Property of 1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

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Technology Process of 1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

There total 5 articles about 1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26458-74-2
quinuclidin-4-ol

: C₁₁H₅F₃N₂OS

: 1047673-68-6
1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

Guidance literature:: quinuclidin-4-ol; C₁₁H₅F₃N₂OS; In N,N-dimethyl-formamide; toluene; for 2h; Reflux;

With hydrogenchloride; In ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: 127918-34-7
ethyl 5-(3-trifluoromethylphenyl)-1,3-thiazole-4-carboxylate

: 1047673-68-6
1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol / 6 h / Reflux

2: triethylamine; diphenyl phosphoryl azide / toluene / 0.67 h / 20 °C

3: toluene / 1 h / 90 °C

4: toluene; N,N-dimethyl-formamide / 2 h / Reflux

With diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; toluene; 3: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031

Reference yield:

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1047673-68-6
1-azabicyclo[2.2.2]oct-4-yl {5-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}carbamate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 90 °C

2: sodium hydroxide / ethanol / 6 h / Reflux

3: triethylamine; diphenyl phosphoryl azide / toluene / 0.67 h / 20 °C

4: toluene / 1 h / 90 °C

5: toluene; N,N-dimethyl-formamide / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; sodium carbonate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki-Miyaura Coupling / 4: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2014.04.031