Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate

Base Information

Chemical Name:Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate
CAS No.:79247-76-0
Molecular Formula:C₁₂H₁₉NO₂S
Molecular Weight:241.354
Hs Code.:
DSSTox Substance ID:DTXSID40705345
Wikidata:Q82638186
Mol file:79247-76-0.mol

Synonyms:79247-76-0;2-Thiazolecarboxylic acid, 4-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester;tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate;DTXSID40705345;2-Thiazolecarboxylic acid,4-(1,1-dimethylethyl)-,1,1-dimethylethyl ester;AKOS015841423;tert-Butyl4-(tert-butyl)thiazole-2-carboxylate;tert-Butyl 4-(tert-butyl)thiazole-2-carboxylate;2-Methyl-2-propanyl 4-(2-methyl-2-propanyl)-1,3-thiazole-2-carboxylate

Suppliers and Price of Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-THIAZOLECARBOXYLIC ACID, 4-(1,1-DIMETHYLETHYL)-, 1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 501.02

Total 3 raw suppliers

Chemical Property of Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate

Chemical Property:

PSA：67.43000
LogP:3.39590
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:241.11365002
Heavy Atom Count:16
Complexity:265

Purity/Quality:: 2-THIAZOLECARBOXYLIC ACID, 4-(1,1-DIMETHYLETHYL)-, 1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CSC(=N1)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate

There total 4 articles about Tert-butyl 4-tert-butyl-1,3-thiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79247-74-8
4-t-butylthiazole-2-carboxylic acid

: 79247-76-0
t-butyl 4-t-butylthiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / benzene / 0.25 h / Heating

2: 0.72 g / LiOBu-t / tetrahydrofuran / 1 h / Heating

With oxalyl dichloride; lithium tert-butoxide; In tetrahydrofuran; benzene;
DOI:10.1039/P19810002335

Reference yield:

: 79247-72-6
ethyl 4-t-butylthiazole-2-carboxylate

: 79247-76-0
t-butyl 4-t-butylthiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.1 g / KOH, water / 0.08 h / Heating

2: oxalyl chloride / benzene / 0.25 h / Heating

3: 0.72 g / LiOBu-t / tetrahydrofuran / 1 h / Heating

With potassium hydroxide; oxalyl dichloride; water; lithium tert-butoxide; In tetrahydrofuran; benzene;
DOI:10.1039/P19810002335

Reference yield:

: 5469-26-1
1-Bromopinacolon

: 79247-76-0
t-butyl 4-t-butylthiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 13.6 g / ethanol / 0.5 h / Heating

2: 2.1 g / KOH, water / 0.08 h / Heating

3: oxalyl chloride / benzene / 0.25 h / Heating

4: 0.72 g / LiOBu-t / tetrahydrofuran / 1 h / Heating

With potassium hydroxide; oxalyl dichloride; water; lithium tert-butoxide; In tetrahydrofuran; ethanol; benzene;
DOI:10.1039/P19810002335