methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Base Information

Chemical Name:methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate
CAS No.:158066-06-9
Molecular Formula:C₂₀H₂₉N₃O₆
Molecular Weight:407.467
Hs Code.:

Synonyms:methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

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Chemical Property of methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

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Technology Process of methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

There total 8 articles about methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2448-58-0,94883-19-9
(S)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-3-phenylpropanoic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 158066-06-9
methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 20 ℃; for 2h; optical yield given as %de;
DOI:10.1021/ol3013556

Reference yield: 87.0%

: 15761-38-3
L-N-Boc-Ala

: 7625-59-4
L-phenylalanylglycine methyl ester hydrochloride

: 158066-06-9
methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: L-N-Boc-Ala; L-phenylalanylglycine methyl ester hydrochloride; With sodium dihydrogenphosphate; 17α-acetoxy-6-formyl-3-methoxypregna-3,5-dien-20-one; In ethyl acetate; for 0.0166667h; Inert atmosphere;

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethyl acetate; for 0.333333h; Inert atmosphere;
DOI:10.1002/ejoc.202100839

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 158066-06-9
methyl 9-benzyl-2,2,6-trimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium dihydrogenphosphate; ethyl cyanoglyoxylate-2-oxime / ethyl acetate / 0.02 h / Inert atmosphere; Milling; Green chemistry

1.2: 0.25 h / Inert atmosphere; Milling; Green chemistry

2.1: hydrogenchloride

3.1: sodium dihydrogenphosphate; ethyl cyanoglyoxylate-2-oxime / ethyl acetate / 0.02 h / Inert atmosphere; Milling; Green chemistry

3.2: 0.08 h / Inert atmosphere; Milling; Green chemistry

With hydrogenchloride; sodium dihydrogenphosphate; ethyl cyanoglyoxylate-2-oxime; In ethyl acetate;
DOI:10.1002/ejoc.201600617