(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

Base Information

Chemical Name:(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide
CAS No.:1373964-22-7
Molecular Formula:C₂₇H₂₅N₇O₃
Molecular Weight:495.541
Hs Code.:

Synonyms:(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

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Chemical Property of (R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

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Technology Process of (R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

There total 4 articles about (R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373964-23-8
C₃₂H₃₃N₇O₅

: 1373964-22-7
(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 109-08-0
2-Methylpyrazine

: 1373964-22-7
(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichloroisocyanuric acid / chloroform / Reflux

2: water / 2 h

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol

4: trifluoroacetic acid / dichloromethane / 1 h

With trichloroisocyanuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; chloroform; water;

Reference yield:

: 39204-47-2
2-(chloromethyl)pyrazine

: 1373964-22-7
(R)-3-(5-(2-amino-1-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl)-N-methyl-5-(oxazol2-yl)-N-(pyrazin-2-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: water / 2 h

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol

3: trifluoroacetic acid / dichloromethane / 1 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water;