2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

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Chemical Name:2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide
CAS No.:1187212-87-8
Molecular Formula:C₂₈H₂₅F₂N₅O₃S
Molecular Weight:549.601
Hs Code.:

Synonyms:2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

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Chemical Property of 2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

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Technology Process of 2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

There total 10 articles about 2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.82%

: 1187214-11-4
tert-butyl (2-(7-(2-fluoro-4-(2-fluorobenzamido)phenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate

: 1187212-87-8
2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

Guidance literature:: tert-butyl (2-(7-(2-fluoro-4-(2-fluorobenzamido)phenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl(2-methoxyethyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 39021-62-0
1-methylimidazole-5-carbaldehyde

: 1187212-87-8
2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: camphor-10-sulfonic acid / toluene / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C

2.2: -78 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

3.2: -78 - 20 °C

3.3: 4 h / Reflux; Inert atmosphere

4.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

5.1: camphor-10-sulfonic acid / 5 h / Reflux

6.1: hydrogenchloride; water / acetone / 20 °C

7.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

8.1: dichloromethane / 20 °C

9.1: ammonium chloride; zinc / methanol; water / 24 h / Reflux

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; hexanes; diphenylether; dichloromethane; water; acetone; toluene;

Reference yield:

: 1127329-17-2
5-(1,3-dioxan-2-yl)-1-methyl-1H-imidazole

: 1187212-87-8
2-fluoro-N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)-1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C

1.2: -78 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.17 h / -78 °C

2.2: -78 - 20 °C

2.3: 4 h / Reflux; Inert atmosphere

3.1: sodium hydrogencarbonate / diphenylether / 4 h / 180 °C

4.1: camphor-10-sulfonic acid / 5 h / Reflux

5.1: hydrogenchloride; water / acetone / 20 °C

6.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 24 h / 20 °C

7.1: dichloromethane / 20 °C

8.1: ammonium chloride; zinc / methanol; water / 24 h / Reflux

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; hexanes; diphenylether; dichloromethane; water; acetone;