ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

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Chemical Name:ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate
CAS No.:1361144-70-8
Molecular Formula:C₂₈H₄₉IN₄O₄Si₂
Molecular Weight:688.797
Hs Code.:

Synonyms:ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

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Chemical Property of ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

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Technology Process of ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

There total 9 articles about ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361144-69-5
ethyl 4-(7-(bis(2-(trimethylsilyl)ethoxy)methyl)aminopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

: 1361144-70-8
ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: With N-iodo-succinimide; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 147905-77-9
ethyl 1-methyl-4-oxo-1-cyclohexanecarboxylate

: 1361144-70-8
ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 20 °C

2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 °C / Inert atmosphere; sealed tube

5.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

With potassium phosphate; N-iodo-succinimide; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; acetonitrile;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1361144-70-8
ethyl 4-(7-(bis((2(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / benzene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 20 °C

3.1: water; ammonium cerium (IV) nitrate / acetonitrile / 1 h / 70 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 20 °C

5.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

6.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 °C / Inert atmosphere; sealed tube

8.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

With potassium phosphate; N-iodo-succinimide; ammonium cerium (IV) nitrate; water; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; acetonitrile; benzene;