6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

Base Information

Chemical Name:6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one
CAS No.:928344-82-5
Molecular Formula:C₂₄H₂₀FN₅O
Molecular Weight:413.454
Hs Code.:

Synonyms:6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

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Chemical Property of 6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

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Technology Process of 6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

There total 14 articles about 6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 928343-62-8
6-[2-(4-fluorophenyl)-6-(iodomethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

: 928344-82-5
6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: With sodium methylate; In methanol; for 12h; Reflux;
DOI:10.1021/jm3008008

Reference yield:

: 928343-61-7,928344-12-1,928344-13-2
6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

: 928344-82-5
6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; triphenylphosphine / tetrahydrofuran / 0 °C

2: sodium methylate / methanol / 12 h / Reflux

With iodine; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1021/jm3008008

Reference yield:

: 1397262-09-7
ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(phenoxycarbothioyl)amino]methyl}propanoate

: 928344-82-5
6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / ethanol / 8 h / 20 - 40 °C

2: ethanol; acetic acid / 14 h / 60 °C

3: methanesulfonyl chloride; triethylamine / acetonitrile / 6 h / 100 °C

4: lithium borohydride / tetrahydrofuran / 2 h / 20 °C

5: iodine; triphenylphosphine / tetrahydrofuran / 0 °C

6: sodium methylate / methanol / 12 h / Reflux

With lithium borohydride; iodine; sodium methylate; hydrazine hydrate; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; acetic acid; acetonitrile;
DOI:10.1021/jm3008008