6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid

Base Information

• Chemical Name: 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid
• CAS No.: 115296-92-9
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485

Synonyms:6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid

Chemical Property of 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid

Chemical Property:

Purity/Quality:

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Technology Process of 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid

There total 3 articles about 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) + (1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) → 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid (115296-92-9)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/ardp.19883210508

Reference yield:

tert-butyldicarbonate (34619-03-9) → 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid (115296-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.8 percent

2: 80.2 percent / carbonyldiimidazole / tetrahydrofuran / Ambient temperature

With 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1002/ardp.19883210508

Reference yield:

6-aminohexanoic acid (60-32-2,93208-38-9) → 6-N-tert.-Butyloxycarbonyl-6-amino-capronsaeure-(1'S,2'R)(1'-methyl-2'-hydroxy-2'-phenylethyl)-amid (115296-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.8 percent

2: 80.2 percent / carbonyldiimidazole / tetrahydrofuran / Ambient temperature

With 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1002/ardp.19883210508

upstream raw materials:

6-(tert-butoxycarbonylamino)hexanoic acid

(1R,2S)-norephedrine

tert-butyldicarbonate

6-aminohexanoic acid

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