N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

Base Information

Chemical Name:N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide
CAS No.:206351-44-2
Molecular Formula:C₂₆H₃₂F₃N₃O₄
Molecular Weight:507.553
Hs Code.:

Synonyms:N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

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Chemical Property of N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

Chemical Property:

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Technology Process of N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

There total 7 articles about N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.25%

: 206351-43-1
N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-azaandrost-5-ene-17β-carboxamide

: 206351-44-2
N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

Guidance literature:: With formic acid; potassium carbonate; In N,N-dimethyl-formamide; for 8h; Heating;
DOI:10.3987/COM-97-S(N)35

Reference yield:

: 302-97-6
androst-4-en-3-one-17β-carboxylic acid

: 206351-44-2
N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / toluene; pyridine / 3 h / 5 °C

2: 0.5 h / 5 °C

3: 63.55 percent / NaIO₄, KMnO₄, Na₂CO₃ / 2-methyl-propan-2-ol; H₂O / 0.5 h / Heating

4: 62.94 percent / NH₃ gas / ethane-1,2-diol / rt, 15 min; rt to 180 deg C at the rate of 0.5 deg C/min; 180 deg C, 15 min

5: 76.25 percent / 88percent HCOOH, K₂CO₃ / dimethylformamide / 8 h / Heating

With potassium permanganate; sodium periodate; formic acid; thionyl chloride; ammonia; sodium carbonate; potassium carbonate; In pyridine; water; ethylene glycol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.3987/COM-97-S(N)35

Reference yield:

: 57072-90-9
3-oxoandrost-4-ene-17β-carboxylic acid chloride

: 206351-44-2
N-(3'-trifluoromethyl-4'-nitrophenyl)-3-oxo-4-aza-5α-androstane-17β-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 0.5 h / 5 °C

2: 63.55 percent / NaIO₄, KMnO₄, Na₂CO₃ / 2-methyl-propan-2-ol; H₂O / 0.5 h / Heating

3: 62.94 percent / NH₃ gas / ethane-1,2-diol / rt, 15 min; rt to 180 deg C at the rate of 0.5 deg C/min; 180 deg C, 15 min

4: 76.25 percent / 88percent HCOOH, K₂CO₃ / dimethylformamide / 8 h / Heating

With potassium permanganate; sodium periodate; formic acid; ammonia; sodium carbonate; potassium carbonate; In water; ethylene glycol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.3987/COM-97-S(N)35