(R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate

Base Information

• Chemical Name: (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate
• CAS No.: 1006706-47-3
• Molecular Formula: C₂₈H₃₄F₃N₃O₅
• Molecular Weight: 549.59

Synonyms:(R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate

Chemical Property of (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate

There total 1 articles about (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 1,4-diazepane-1-carboxylate (117009-97-9) + (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid (486460-00-8,922178-94-7) → (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate (1006706-47-3)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2008.10.076

Reference yield: 89.0%

(R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate (1006706-47-3) → (R)-tert-butyl 4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate (1006706-48-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 10h;

DOI:10.1016/j.bmcl.2008.10.076

Reference yield:

(R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate (1006706-47-3) → C23H26F3N3O3*ClH (1100226-69-4)

Guidance literature:

With hydrogenchloride; water; In ethyl acetate; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2008.10.076

upstream raw materials:

benzyl 1,4-diazepane-1-carboxylate

(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

Downstream raw materials:

C₂₃H₂₆F₃N₃O₃*ClH

(R)-tert-butyl 4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1006706-47-3 (R)-benzyl 4-(3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-1,4-diazepine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send