2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole

Base Information

• Chemical Name: 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole
• CAS No.: 135491-45-1
• Molecular Formula: C₁₉H₁₃N₃O₃
• Molecular Weight: 331.331
• Mol file: 135491-45-1.mol

Synonyms:2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole

Chemical Property of 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole

There total 3 articles about 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-(2-nitrophenyl)-2-furaldehyde (20000-96-8) + ((1H-benzo[d]imidazol-2-yl)methyl)triphenylphosphonium chloride (60912-44-9) → 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole (135491-45-1)

Guidance literature:

With sodium methylate; In methanol; at 40 ℃; for 0.5h;

Reference yield:

2-chloromethyl-1H-benzimidazole (4857-04-9) → 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole (135491-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76.5 percent / acetonitrile / 3 h / Heating

2: 58 percent / sodium methoxide / methanol / 0.5 h / 40 °C

With sodium methylate; In methanol; acetonitrile;

Reference yield:

1,2-diamino-benzene (95-54-5) → 2-{(E)-2-[5-(2-Nitro-phenyl)-furan-2-yl]-vinyl}-1H-benzoimidazole (135491-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97.7 percent / 4M aq HCl / 3 h / Heating

2: 76.5 percent / acetonitrile / 3 h / Heating

3: 58 percent / sodium methoxide / methanol / 0.5 h / 40 °C

With hydrogenchloride; sodium methylate; In methanol; acetonitrile;

upstream raw materials:

5-(2-nitrophenyl)-2-furaldehyde

((1H-benzo[d]imidazol-2-yl)methyl)triphenylphosphonium chloride

2-chloromethyl-1H-benzimidazole

1,2-diamino-benzene