N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

Base Information

Chemical Name:N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide
CAS No.:888493-96-7
Molecular Formula:C₂₉H₂₈FN₅O₇
Molecular Weight:577.569
Hs Code.:

Synonyms:N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

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Chemical Property of N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

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Technology Process of N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

There total 2 articles about N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20320-43-8
2-(pyrrolidin-1-ylcarbonyl)benzoic acid

: 888493-96-7
N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / acetone / 0.17 h / -15 °C

2: 356 mg / acetone

With triethylamine; In acetone;
DOI:10.1055/s-2006-926362

Reference yield:

: 103554-77-4
N-[3-(2-aminoethoxy)-3-(5-fluorouracil-1-yl)propyl]phthalimide hydrochloride

: 888493-95-6
C₁₅H₁₇NO₅

: 888493-96-7
N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

Guidance literature:: In acetone;
DOI:10.1055/s-2006-926362

Reference yield:

: 888493-96-7
N-{3-[2-(o-(1-pyrrolidinylcarbonyl)benzamido)ethoxy]-3-(5-fluorouracil-1-yl)propyl}phthalimide

: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine monohydrate / dimethylformamide / -15 °C

2: 194 mg / aq. HCl / methanol / 6 h

With hydrogenchloride; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-926362