1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate
CAS No.:1262131-40-7
Molecular Formula:C₁₈H₂₄ClN₃O₆
Molecular Weight:413.858
Hs Code.:

Synonyms:1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

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Chemical Property of 1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

There total 1 articles about 1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 129799-08-2
tert-butyl methyl piperazine-1,3-dicarboxylate

: 1262131-40-7
1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

Guidance literature:: 5-chloro-2-nitrobenzaldehyde; tert-butyl methyl piperazine-1,3-dicarboxylate; With acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 1262131-40-7
1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

: 1262131-43-0
1-tert-butyl 3-methyl 4-(4-amino-4'-chlorobiphenyl-3-yl-methyl)piperazine-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: hydrogen / nickel / tetrahydrofuran / 22 h / 20 °C

With water; hydrogen; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 1262131-40-7
1-tert-butyl 3-methyl 4-(5-chloro-2-nitrobenzyl)piperazine-1,3-dicarboxylate

: 1262131-45-2
7-(4-chlorophenyl)-1,3,4,5,10,11a-hexahydro-2H-2,4a,10-triazadibenzo[a,d]cyclohepten-11-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogen / nickel / tetrahydrofuran / 22 h / 20 °C

3.1: acetic acid / 2 h / 110 °C

3.2: 3 h / 20 °C

3.3: pH 8

With water; hydrogen; sodium hydrogencarbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel; In tetrahydrofuran; 1,2-dimethoxyethane;