4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

Base Information

Chemical Name:4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride
CAS No.:1295570-08-9
Molecular Formula:C₁₃H₁₅F₃N₂*ClH
Molecular Weight:292.732
Hs Code.:

Synonyms:4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

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Chemical Property of 4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

Chemical Property:

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Technology Process of 4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

There total 7 articles about 4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1221573-19-8
7-[4-nitro-3-(trifluoromethyl) phenyl]-7-azabicyclo[2.2.1]heptane

: 1295570-08-9
4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

Guidance literature:: 7-[4-nitro-3-(trifluoromethyl) phenyl]-7-azabicyclo[2.2.1]heptane; With hydrogen; 5% Pd(II)/C(eggshell); In 2-methyltetrahydrofuran; at 18 - 23 ℃; under 375.038 Torr;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1295570-09-0
7-[4-nitro-3-(trifluoromethyl) phenyl]-7-azabicyclo[2.2.1]heptane hydrochloride

: 1295570-08-9
4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

Guidance literature:: 7-[4-nitro-3-(trifluoromethyl) phenyl]-7-azabicyclo[2.2.1]heptane hydrochloride; With hydrogen; 5% Pd(II)/C(eggshell); In 2-methyltetrahydrofuran; at 18 - 23 ℃; Inert atmosphere;

With hydrogenchloride; In 2-methyltetrahydrofuran; 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1295570-08-9
4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 5 °C

2.1: dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / dichloromethane / 25 °C

3.2: 0.5 h

4.1: triethylamine / acetonitrile / 16 h / 80 °C / Inert atmosphere

5.1: hydrogen / 5% Pd(II)/C(eggshell) / 2-methyltetrahydrofuran / 18 - 23 °C / 375.04 Torr / Inert atmosphere

5.2: 1 h / 20 °C / Inert atmosphere

With water; hydrogen; triethylamine; sodium hydroxide; 5% Pd(II)/C(eggshell); In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; acetonitrile;