2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile

Base Information

• Chemical Name: 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile
• CAS No.: 883560-04-1
• Molecular Formula: C₁₉H₁₂N₄O
• Molecular Weight: 312.33
• Mol file: 883560-04-1.mol

Synonyms:2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile

Chemical Property of 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile

There total 3 articles about 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester (883560-03-0) → 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile (883560-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / aq. NaCl / dimethylsulfoxide

2: 99 percent / aq. N₂H₄ / ethanol / Heating

3: 45 percent / ethanol / Heating

With hydrazine hydrate; sodium chloride; In ethanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2005.12.096

Reference yield:

4-Phenoxybenzoic acid (2215-77-2) → 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile (883560-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / DEPC; DIEA / dimethylformamide

2: 92 percent / aq. NaCl / dimethylsulfoxide

3: 99 percent / aq. N₂H₄ / ethanol / Heating

4: 45 percent / ethanol / Heating

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; diethyl dicarbonate; sodium chloride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.12.096

Reference yield:

3-oxo-3-(4-phenoxyphenyl)propanenitrile (136562-77-1) → 2-(4-phenoxy-phenyl)-pyrazolo[1,5-a]pyrimidine-6-carbonitrile (883560-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / aq. N₂H₄ / ethanol / Heating

2: 45 percent / ethanol / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmcl.2005.12.096

upstream raw materials:

2-cyano-3-oxo-3-(4-phenoxy-phenyl)-propionic acid methyl ester

4-Phenoxybenzoic acid

3-oxo-3-(4-phenoxyphenyl)propanenitrile