SGD 1882

Base Information

• Chemical Name: SGD 1882
• CAS No.: 1222490-34-7
• Molecular Formula: C₄₂H₃₉N₅O₇
• Molecular Weight: 725.801
• Mol file: 1222490-34-7.mol

Synonyms:(S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

Chemical Property of SGD 1882

Chemical Property:

• Boiling Point: 977.7±65.0 °C(Predicted)
• PKA: 5.07±0.10(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SGD 1882

There total 18 articles about SGD 1882 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-2-(4-aminophenyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-methoxyphenyl)-5,11-dioxo-10-((2-(trimethyisilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)propoxy)-10-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (1222490-90-5) → (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one (1222490-34-7)

Guidance literature:

(S)-2-(4-aminophenyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-methoxyphenyl)-5,11-dioxo-10-((2-(trimethyisilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)propoxy)-10-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione; With lithium borohydride; In tetrahydrofuran; ethanol; at 20 ℃; Cooling with ice bath;

With water; In tetrahydrofuran; ethanol; at 20 ℃; Cooling with ice bath;

Reference yield: 58.0%

C55H50Cl9N5O17 → (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one (1222490-34-7)

Guidance literature:

With Cd#Pb; ammonium acetate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2015.05.116

Reference yield:

C26H35ClN2O7Si → (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one (1222490-34-7)

Guidance literature:

Multi-step reaction with 13 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol; N,N-dimethyl-formamide / 3 h / 20 °C

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 20 °C

3.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 20 °C

4.1: pyridine / dichloromethane / 20 °C

5.1: toluene-4-sulfonic acid / methanol / 50 °C

6.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / -78 °C

6.2: 1 h / -78 - 20 °C

7.1: pyridine / 20 °C

8.1: 2,6-dimethylpyridine / -45 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water; ethanol / 20 °C

10.1: pyridine / dichloromethane / 20 °C

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran

12.1: caesium carbonate / N,N-dimethyl-formamide

13.1: ammonium acetate; Cd#Pb / tetrahydrofuran

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; oxalyl dichloride; Cd#Pb; palladium 10% on activated carbon; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: |Ley Oxidation / 6.1: |Swern Oxidation / 6.2: |Swern Oxidation / 9.1: |Suzuki Coupling;

DOI:10.1016/j.tetlet.2015.05.116

upstream raw materials:

(S)-2-(4-aminophenyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-methoxyphenyl)-5,11-dioxo-10-((2-(trimethyisilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)propoxy)-10-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

(S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-hexanamido)-3-methylbutanamido)propanoic acid