2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

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Chemical Name:2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid
CAS No.:1394920-70-7
Molecular Formula:C₂₀H₂₁NO₇
Molecular Weight:387.389
Hs Code.:

Synonyms:2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

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Chemical Property of 2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

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Technology Process of 2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

There total 4 articles about 2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 85-44-9
phthalic anhydride

: 1394920-69-4
2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-6-amine

: 1394920-70-7
2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

Guidance literature:: phthalic anhydride; 2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-6-amine; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Inert atmosphere;

With water; at 20 ℃; for 2h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.tetlet.2011.11.111

Reference yield:

: 1394920-67-2
2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin

: 1394920-70-7
2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; acetic acid / 17 h / 15 - 20 °C / Inert atmosphere

2.1: 20% palladium hydroxide on charcoal; hydrogen / methanol / 2 h / 3102.97 Torr

3.1: N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere; Cooling with ice

With 20% palladium hydroxide on charcoal; hydrogen; nitric acid; acetic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.11.111

Reference yield:

: 1394920-68-3
2,3-dihydro-2,3-dimethoxy-2,3-dimethyl-6-nitrobenzo[b][1,4]dioxin

: 1394920-70-7
2-(2,3-dihydro-2,3-dimethoxy-2,3-dimethylbenzo[b][1,4]dioxin-7-ylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 20% palladium hydroxide on charcoal; hydrogen / methanol / 2 h / 3102.97 Torr

2.1: N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere; Cooling with ice

With 20% palladium hydroxide on charcoal; hydrogen; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.11.111