1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

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Chemical Name:1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea
CAS No.:1268474-24-3
Molecular Formula:C₂₂H₂₈N₆O₄
Molecular Weight:440.502
Hs Code.:

Synonyms:1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

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Chemical Property of 1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

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Technology Process of 1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

There total 5 articles about 1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.4%

: 874290-99-0
1-methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1268475-02-0
2-chloro-5-(2-hydroxy-2-methylpropyl)-6a-methyl-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

: 1268474-24-3
1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Microwave Irradiation;

Reference yield:

: 1268474-98-1
1-(2,4-dichloropyrimidin-5-ylamino)-2-methylpropan-2-ol

: 1268474-24-3
1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 5 steps

1: pyridin-2-yl tosylate / dichloromethane / 16 h

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 95 °C

3: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C

4: hydrogenchloride / water; tetrahydrofuran / 1 h

5: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; pyridin-2-yl tosylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1268474-99-2
2,4-dichloro-N-(2-methyl-2-(tetrahydro-2H-pyran-2-yloxy)propyl)pyrimidin-5-amine

: 1268474-24-3
1-(4-(5-(2-hydroxy-2-methylpropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4 h / 95 °C

2: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C

3: hydrogenchloride / water; tetrahydrofuran / 1 h

4: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;