1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

Base Information

Chemical Name:1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate
CAS No.:603944-59-8
Molecular Formula:C₁₉H₂₇O₆P
Molecular Weight:382.394
Hs Code.:

Synonyms:1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

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Chemical Property of 1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

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Technology Process of 1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

There total 4 articles about 1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 3095-95-2
diethylphosphonoacetic acid

: 868871-81-2,159149-10-7,1246858-42-3
2-benzyl-2-hydroxymethylcyclopentanone

: 603944-59-8
1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0040-4039(03)01320-0

Reference yield:

: 50984-08-2
ethyl 1-benzyl-2-oxocyclopentanecarboxylate

: 603944-59-8
1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / APTS / toluene / Heating

2: LiAlH₄ / diethyl ether / 0 °C

3: 2.65 g / HCl; H₂O / diethyl ether / 2 h / 20 °C

4: 91 percent / DMAP; dicyclohexylcarbodiimide / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; water; dicyclohexyl-carbodiimide; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tet.2007.02.027

Reference yield:

: 603944-58-7
(6-benzyl-1,4-dioxa-spiro[4.4]non-6-yl)-methanol

: 603944-59-8
1-benzyl-2-oxocyclopentylmethyl diethoxyphosphinylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 2.65 g / HCl; H₂O / diethyl ether / 2 h / 20 °C

2: 91 percent / DMAP; dicyclohexylcarbodiimide / CH₂Cl₂ / 3 h / 20 °C

With hydrogenchloride; dmap; water; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2007.02.027