3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Base Information

Chemical Name:3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide
CAS No.:912962-88-0
Molecular Formula:C₂₆H₃₁N₃O₂S₃
Molecular Weight:513.749
Hs Code.:

Synonyms:3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

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Chemical Property of 3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

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Technology Process of 3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

There total 5 articles about 3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6165-68-0
thiophene boronic acid

: 912962-84-6
3-(3-(bromoimidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

: 912962-88-0
3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In ethanol; water; toluene; at 90 ℃; Inert atmosphere;
DOI:10.1021/jm2015099

Reference yield:

: 912942-73-5
3-(3-bromomethylphenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

: 912962-88-0
3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide / ethanol; water; toluene / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide; In 1,4-dioxane; ethanol; water; toluene; 2: Suzuki coupling;
DOI:10.1021/jm2015099

Reference yield:

: 912942-72-4
3-(3-hydroxymethylphenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

: 912962-88-0
3-(3-(2-(thiophen-2-yl)imidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / N,N-dimethyl-formamide / 20 °C

2: sodium hydroxide / 1,4-dioxane / 1 h / 80 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide / ethanol; water; toluene / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1021/jm2015099