Technology Process of 2β-(p-methylbenzyl)-3,4β-oxidopyrrolidine
There total 5 articles about 2β-(p-methylbenzyl)-3,4β-oxidopyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 1.5h;
DOI:10.1021/ja00386a039
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / zinc dust, aq. HCl / ethanol / 1.) 1.5 h, 2.) reflux, 1.5 h
2: 93 percent / aq. NaOH / toluene / 1 h / 3 - 5 °C
3: 78 percent / N-iodosuccinimide, aq. perchloric acid / tetrahydrofuran / 1.) 3-5 deg C, 1 h, 2.) 3-5 deg C -> room temperature, 1 h
4: 90 percent / 5percent KOH, MeOH / 0.5 h
5: 95 percent / hydrogen / 10percent Pd/C / ethanol / 1.5 h
With
hydrogenchloride; methanol; potassium hydroxide; sodium hydroxide; N-iodo-succinimide; perchloric acid; hydrogen; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1021/ja00386a039
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / aq. NaOH / toluene / 1 h / 3 - 5 °C
2: 78 percent / N-iodosuccinimide, aq. perchloric acid / tetrahydrofuran / 1.) 3-5 deg C, 1 h, 2.) 3-5 deg C -> room temperature, 1 h
3: 90 percent / 5percent KOH, MeOH / 0.5 h
4: 95 percent / hydrogen / 10percent Pd/C / ethanol / 1.5 h
With
methanol; potassium hydroxide; sodium hydroxide; N-iodo-succinimide; perchloric acid; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1021/ja00386a039
