N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

Base Information

Chemical Name:N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester
CAS No.:109953-11-9
Molecular Formula:C₂₄H₃₇N₅O₇
Molecular Weight:507.587
Hs Code.:

Synonyms:N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

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Chemical Property of N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

Chemical Property:

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Technology Process of N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

There total 4 articles about N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 109953-11-9
N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min, 2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature

2: 97.3 percent / NaOH, water / ethanol / 1.5 h / Ambient temperature

3: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min, 2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature

4: HCl / acetic acid / 1 h / Ambient temperature

5: 84.7 percent / triethylamine / CHCl₃ / 1.) 2 h, 2.) room temperature, overnight

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; water; chloroformic acid ethyl ester; triethylamine; In ethanol; chloroform; acetic acid;

Reference yield:

: 45233-75-8
2-[[(2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoyl]amino]acetic acid

: 109953-11-9
N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min, 2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature

2: HCl / acetic acid / 1 h / Ambient temperature

3: 84.7 percent / triethylamine / CHCl₃ / 1.) 2 h, 2.) room temperature, overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In chloroform; acetic acid;

Reference yield:

: 4526-92-5
Boc-Val-Gly-OEt

: 109953-11-9
N-<(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valylglycylaza-alanine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97.3 percent / NaOH, water / ethanol / 1.5 h / Ambient temperature

2: 1.) N-methylmorpholine, ethyl chloroformate, 2.) N-methylmorpholine / 1.) DMF, -20 deg C, 2 min, 2.) DMF, -20 deg C, then 0 deg C, 2 h, then overnight, room temperature

3: HCl / acetic acid / 1 h / Ambient temperature

4: 84.7 percent / triethylamine / CHCl₃ / 1.) 2 h, 2.) room temperature, overnight

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; water; chloroformic acid ethyl ester; triethylamine; In ethanol; chloroform; acetic acid;