N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

Base Information

Chemical Name:N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide
CAS No.:153154-88-2
Molecular Formula:C₅₃H₅₃N₃O₈
Molecular Weight:860.019
Hs Code.:

N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5-<N-(monomethoxytrityl)-2'(S)-aziridinyl>-2(Z)-pentenamide

Synonyms:N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

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Chemical Property of N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

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Technology Process of N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

There total 17 articles about N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-((Z)-(3R,4R)-1-(2-Hydroxy-propylcarbamoyl)-3,4-bis-(4-methoxy-benzyloxy)-4-{(S)-1-[(4-methoxy-phenyl)-diphenyl-methyl]-aziridin-2-yl}-but-1-enyl)-benzamide

: 153154-88-2
N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.166667h; Yield given;
DOI:10.1021/jo00079a033

Reference yield:

: 85992-73-0
2-Benzoylamino-2-(diethoxyphosphoryl)essigsaeure-ethylester

: 153154-88-2
N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / heptane; tetrahydrofuran / 1.) -78 deg C, 30 min; 0 deg C, 1 h, 2.) -20 deg C, overnight

2: aq. LiOH / tetrahydrofuran / 8 h / 50 °C

3: 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 2.17 h / Ambient temperature

4: DMSO, oxalyl chloride / CH₂Cl₂ / 0.17 h / -78 °C

With lithium hydroxide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1021/jo00079a033

Reference yield:

: 137845-83-1
(2'S)-3--2(R),3(R)-bis<(p-methoxybenzyl)oxy>-1-propanal

: 153154-88-2
N-(2-Oxopropyl)-2-(N-benzoylamino)-4(R),5(R)-bis<(p-methoxybenzyl)oxy>-5--2(Z)-pentenamide

Guidance literature:: Multi-step reaction with 4 steps

1: LDA / heptane; tetrahydrofuran / 1.) -78 deg C, 30 min; 0 deg C, 1 h, 2.) -20 deg C, overnight

2: aq. LiOH / tetrahydrofuran / 8 h / 50 °C

3: 1-hydroxybenzotriazole, DCC / CH₂Cl₂ / 2.17 h / Ambient temperature

4: DMSO, oxalyl chloride / CH₂Cl₂ / 0.17 h / -78 °C

With lithium hydroxide; oxalyl dichloride; benzotriazol-1-ol; dimethyl sulfoxide; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1021/jo00079a033