2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-,[3aS-(3aalpha,4alpha,6bta,7alpha,7aalpha)]-(9CI)

Base Information

Chemical Name:2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-,[3aS-(3aalpha,4alpha,6bta,7alpha,7aalpha)]-(9CI)
CAS No.:785740-69-4
Molecular Formula:C9H16 N2 O4
Molecular Weight:216.23434
Hs Code.:
Mol file:785740-69-4.mol

Synonyms:2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-, [3aS-(3aa,4a,6b,7a,7aa)]- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-,[3aS-(3aalpha,4alpha,6bta,7alpha,7aalpha)]-(9CI)

Chemical Property:

PSA：85.02000
LogP:-0.44930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-,[3aS-(3aalpha,4alpha,6bta,7alpha,7aalpha)]-(9CI)

There total 5 articles about 2(3H)-Benzoxazolone,6-aminohexahydro-7-hydroxy-4-methoxy-3-methyl-,[3aS-(3aalpha,4alpha,6bta,7alpha,7aalpha)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94592-17-3,94668-29-8,121521-08-2,121521-30-0
(3aS,4R,6R,7S,7aS)-7-Hydroxy-4-methoxy-3-methyl-6-(1-phenyl-ethylamino)-hexahydro-benzooxazol-2-one

: 785740-69-4
(3aS,4R,6R,7S,7aS)-6-Amino-7-hydroxy-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; under 750.06 Torr;
DOI:10.1016/S0040-4039(01)91038-X

Reference yield:

: 55990-89-1,261919-41-9
(1α,2α,3β,4α,5α)-1,2:4,5-dianhydro-1,2,3,4,5-cyclohexane-pentol

: 785740-69-4
(3aS,4R,6R,7S,7aS)-6-Amino-7-hydroxy-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: dioxane / 5 h / 100 °C

2: tris(dimethylamino)N-methyl-phosphineimine / acetonitrile / 24 h / 20 °C

3: 95 percent

4: 46 percent / propan-1-ol / 3 h

5: H₂ / 10percent Pd/C / methanol / 24 h / 20 °C / 750.06 Torr

With tris(dimethylamino)(methylimino)phosphorane; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; propan-1-ol; acetonitrile;
DOI:10.1016/S0040-4039(01)91038-X

Reference yield:

: 94592-12-8
DL-(1α,2α,3β,4β,5α)-1,2-anhydro-3-O,4-N-carbonyl-4-(methylamino)-1,2,3,5-cyclohexanetetrol

: 785740-69-4
(3aS,4R,6R,7S,7aS)-6-Amino-7-hydroxy-4-methoxy-3-methyl-hexahydro-benzooxazol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent

2: 46 percent / propan-1-ol / 3 h

3: H₂ / 10percent Pd/C / methanol / 24 h / 20 °C / 750.06 Torr

With hydrogen; palladium on activated charcoal; In methanol; propan-1-ol;
DOI:10.1016/S0040-4039(01)91038-X