2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide
CAS No.:1232235-14-1
Molecular Formula:C₁₈H₁₁F₃N₄O₄S
Molecular Weight:436.371
Hs Code.:

Synonyms:2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

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Chemical Property of 2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

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Technology Process of 2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

There total 11 articles about 2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232235-13-0
2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

: 1232235-14-1
2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 60 ℃; for 2h;

Reference yield:

: 160538-51-2
3-fluoro-4-nitro-benzaldehyde

: 1232235-14-1
2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 1 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

3: hydrogenchloride; water / acetonitrile / 2 h / 60 °C

With hydrogenchloride; water; caesium carbonate; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 945860-88-8
2-chloro-4-(4-(trifluoromethyl)phenyl)thiazole

: 1232235-14-1
2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / -78 °C

1.2: 20 °C / Cooling

1.3: 0.08 h

2.1: sodium azide / water; acetone / 16 h / 70 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 17 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.3 h

5.1: ammonium chloride; zinc / tetrahydrofuran; methanol / 1 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

7.1: hydrogenchloride; water / acetonitrile / 2 h / 60 °C

With hydrogenchloride; n-butyllithium; sodium azide; lithium hydroxide monohydrate; water; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; zinc; In tetrahydrofuran; methanol; hexanes; water; N,N-dimethyl-formamide; acetone; acetonitrile;