(+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Base Information

• Chemical Name: (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran
• CAS No.: 263914-55-2
• Molecular Formula: C₁₇H₂₄O₂Si
• Molecular Weight: 288.462
• Mol file: 263914-55-2.mol

Synonyms:(+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Chemical Property of (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran

There total 2 articles about (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-butyn-2-yl tetrahydropyranyl ether (57188-99-5) + phenyldimethylsilyl chloride (768-33-2) → (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran (263914-55-2)

Guidance literature:

With methyllithium;

DOI:10.1021/jo0109467 DOI:10.1021/jo020454+

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → (+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran (263914-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / TsOH

2: 100 percent / MeLi

With methyllithium; toluene-4-sulfonic acid;

DOI:10.1021/jo0109467 DOI:10.1021/jo020454+

Reference yield: 81.0%

(+/-)-2-[3-(dimethylphenylsilyl)-1-methyl-2-propynyloxy]tetrahydropyran (263914-55-2) → (±)-4-(dimethyl(phenyl)silyl)but-3-yn-2-ol (115884-67-8)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 12h;

DOI:10.1021/jo991312r

upstream raw materials:

3-butyn-2-yl tetrahydropyranyl ether

phenyldimethylsilyl chloride

3,4-dihydro-2H-pyran

Downstream raw materials:

(±)-4-(dimethyl(phenyl)silyl)but-3-yn-2-ol

(E)-(±)-1-(dimethylphenylsilyl)-1-buten-3-ol

3-(E)-[dimethyl(phenyl)silyl]but-3-en-2-one