2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile

Base Information

• Chemical Name: 2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile
• CAS No.: 160725-06-4
• Molecular Formula: C₃₀H₂₅N₃O₆S
• Molecular Weight: 555.611
• Mol file: 160725-06-4.mol

Synonyms:2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile

Chemical Property of 2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile

There total 1 articles about 2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + 2-(phenylsulfonyl)acetonitrile (7605-28-9) → 2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile (160725-06-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 0.666667h;

DOI:10.1039/c39940002557

Reference yield:

2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile (160725-06-4) → 4a-Benzenesulfonyl-1,2,3,4,4a,5,6,7-octahydro-[1,8]naphthyridine; compound with (S)-2-(6-methoxy-naphthalen-2-yl)-propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaBH₄, 2) AcOH / 1) iPrOH, H₂O, r.t., 24 h, 2) iPrOH, H₂O, 80 deg C, 3 h

2: CHCl₃

With sodium tetrahydroborate; acetic acid; In chloroform;

DOI:10.1039/c39940002557

Reference yield:

2-Benzenesulfonyl-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-pentanenitrile (160725-06-4) → 6-phenylsulfonyl-2,10-diazabicyclo<4.4.0>dec-1-ene

Guidance literature:

With sodium tetrahydroborate; acetic acid; Yield given. Multistep reaction; 1) iPrOH, H₂O, r.t., 24 h, 2) iPrOH, H₂O, 80 deg C, 3 h;

DOI:10.1039/c39940002557

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

2-(phenylsulfonyl)acetonitrile