phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

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Chemical Name:phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate
CAS No.:1359021-42-3
Molecular Formula:C₄₃H₄₃NO₆
Molecular Weight:669.818
Hs Code.:

Synonyms:phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

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Chemical Property of phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

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Technology Process of phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

There total 15 articles about phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359021-41-2
phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-(pyrrolidin-2-yl)benzoate

: 76-83-5
trityl chloride

: 1359021-42-3
phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1359021-39-8
phenyl 4-(3,4-dihydro-2H-pyrrol-5-yl)-6-hydroxy-3-methoxy-2-methylbenzoate

: 1359021-42-3
phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane

2: sodium tetrahydroborate / methanol

3: triethylamine / dichloromethane

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.6b01903

Reference yield:

: 1359021-38-7
phenyl 4-(4-{[(tert-butoxy)carbonyl]amino}butanoyl)-6-{[(tertbutoxy)carbonyl]oxy}-3-methoxy-2-methylbenzoate

: 1359021-42-3
phenyl 6-{[(tert-butoxy)carbonyl]oxy}-3-methoxy-2-methyl-4-[1-(triphenylmethyl)pyrrolidin-2-yl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

2: dmap / 0.25 h / 20 °C

3: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C

4: triethylamine / dichloromethane / 2 h / 20 °C

With dmap; sodium tetrahydroborate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1038/ja.2017.86