(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

Base Information

Chemical Name:(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate
CAS No.:1334856-70-0
Molecular Formula:C₂₀H₁₈BrNO₃
Molecular Weight:400.272
Hs Code.:

Synonyms:(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

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Chemical Property of (S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of (S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

There total 3 articles about (S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₆BrNO₄

: 1334856-70-0
(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / dichloromethane / 0.5 h / Inert atmosphere

2: toluene / 12 h / Reflux

With hydrogenchloride; water; In dichloromethane; toluene;
DOI:10.1021/ol202326j

Reference yield:

: 1228338-46-2
methyl 2-((4-bromophenyl)((tert-butoxycarbonyl)oxy)methyl)acrylate

: 1334856-70-0
(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(acetonitrile)copper(I)tetrafluoroborate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) / dichloromethane / 36 h / 0 °C / Inert atmosphere

2: hydrogenchloride; water / dichloromethane / 0.5 h / Inert atmosphere

3: toluene / 12 h / Reflux

With hydrogenchloride; tetrakis(acetonitrile)copper(I)tetrafluoroborate; water; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In dichloromethane; toluene; 1: tandem Michael addition-elimination;
DOI:10.1021/ol202326j

Reference yield:

: 68870-85-9
methyl 2-(benzylideneamino)-3-phenylpropionate

: 1334856-70-0
(S,E)-methyl 2-benzyl-4-(4-bromobenzylidene)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(acetonitrile)copper(I)tetrafluoroborate; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) / dichloromethane / 36 h / 0 °C / Inert atmosphere

2: hydrogenchloride; water / dichloromethane / 0.5 h / Inert atmosphere

3: toluene / 12 h / Reflux

With hydrogenchloride; tetrakis(acetonitrile)copper(I)tetrafluoroborate; water; caesium carbonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In dichloromethane; toluene; 1: tandem Michael addition-elimination;
DOI:10.1021/ol202326j